Kink Ease™ Methylsulfonyl Methane (MSM)
BACKGROUND: Methylsulfonyl Methane (MSM) is widely used as an anti-inflammatory medication (6) and as an adjunctive agent in the treatment of pain. MSM is widely found in nature, and is essentially non-allergenic. Cow's milk is the most abundant source of MSM, containing 3.3 parts per million (ppm).
MSM relieves pain through several mechanisms of action. Acting as an anti-inflammatory agent, reduction in tissue swelling, reduction in vasodilation, pain is reduced. MSM may reduce muscle spasm and MSM reduces the rate of pain impulse activity in the C-fiber component of the peripheral nervous system. There is evidence that MSM may have value as a cancer preventive agent. (3). Using multinuclear magnetic resonance spectroscopy MSM was found to cross the blood-brain barrier (BBB) in significant concentration. The study also revealed that MSM is evenly distributed throughout the brain, brainstem, with equal concentrations in both gray and white matter. Other studies have confirmed that MSM crosses the BBB. (4, 5)
MSM is very safe to administer, having a very low toxicity. (7, 8) Methylsulfonylmethane (MSM) is a popular dietary supplement used in a variety of conditions including pain, inflammation, allergies, arthritis, parasitic infections, and bladder conditions. It is thought to maintenance of normal keratin levels in hair, skin and nails. Toxicity studies have concluded that MSM is well tolerated in doses that exceed 2 g/kg. (1)
Compared to placebo, MSM produced significant decreases in pain and physical functional. MSM also produced improvement in performing activities of daily living when compared to placebo. (2)
Oral Dosage:
When taken by mouth MSM is well tolerated, but it can actually enhance the GI uptake of other medications, both prescription and OTC, alike. When taken with medications that have narrow therapeutic ranges, such as coumadin and lithium, MSM should be taken with caution, as the prescription dosage may well have to be decreased.
Generally, patients tolerate 900-1000 mg, taken 3 times, daily. The anti-arthritic properties will be felt in as little as a few hours, but generally, peak effect is seen in a week, or so. When taken concurrently with glucosamine, best taken for knee problems, the amount of glucosamine can be substantially decreased.
Transdermal (topical) Usage (Kink-Ease™)
The best use of topical MSM depends on the concentration of the MSM preparation as well as on the chemistry of the base in which it is suspended. The higher the concentration of MSM, the more rapid the onset of action. The base in which the MSM is suspended influences the depth and adequacy of penetration. Kink Ease™ is a very high concentration of MSM in an advanced transdermal base. The base permits the high concentration of MSM to be achieved while maintaining a smooth texture.
DIRECTIONS FOR USE:
Kink Ease™ MSM Salve should be applied liberally to the shoulder, as if it were suntan lotion being applied. Pain relief will generally be experienced within 60 seconds. After 120 seconds, a second application may be performed.
Symptom relief can be expected to last from 2 to 6 hours, and with repeated use, the duration of action tends to lengthen.
Kink-Ease™ makes a superior hand foot and skin softener. Use before bed time and awaken to incredibly soft skin.
Kink Ease™ is now available in 6 ounce tubes and 32 ounce jars.
For information, go to www.kinkease.com
NOTE: Kink-Ease™ will soften the skin, which makes it a wonderful product for hand and foot use. As a foot softener, apply to the top and bottom of the foot, but do this only at bed time to prevent slipping.
References:
- Horváth K, Noker PE, et al: Toxicity of methylsulfonylmethane in rats. Food 2002 Oct; 40(10):1459-62.
- Kim LS, Axelrod LJ, et al: Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis2006 Mar; 14(3):286-94.
- Ebisuzaki K: Aspirin and methylsulfonylmethane (MSM): a search for common mechanisms, with implications for cancer prevention. Anticancer Res. 2003 Jan-Feb; 23(1A):453-8.
- Cecil KM, Lin A, Ross BD, Egelhoff JC. Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation. J Comput Assist Tomogr 2002;26:818-820.
- Rose SE, Chalk JB, Galloway GJ, Doddrell DM. Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy. Magn Reson Imaging 2000;18:95-98.
- Beilke MA, Collins-Lech C, Sohnle PG. Effects of dimethyl sulfoxide on the oxidative function of human neutrophils. J Lab Clin Med 1987;110:91-96.
- Morton JI,
- Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med 2002;8:167-173.
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